Semax
ACTH 4-10 analog
Mechanism of Action
Synthetic analog of ACTH 4-10. Increases BDNF, NGF, and VEGF expression. Enhances dopaminergic and serotonergic neurotransmission. Neuroprotective and cognitive-enhancing.
Key Benefits
- BDNF and NGF upregulation
- Improved focus, memory, and learning
- Neuroprotection and stroke recovery
- Anxiety reduction and mood improvement
Dosing Protocol
Widely used in Russia as an approved nootropic. Strong BDNF and cognitive data.
Ideal Candidates
Cognitive enhancement, neuroprotection, stroke recovery, focus support.
Side Effects & Safety
Mild nasal irritation (intranasal), headache, fatigue at high doses.
Regulatory Status
Gray AreaNot on the 503A bulks list. Gray zone — approved as a nootropic in Russia.
Evidence & Citations
How we source and weigh evidenceFrequently asked
What is Semax?+
Semax (ACTH 4-10 analog) is a peptide studied for bdnf upregulation and focus & memory. Synthetic analog of ACTH 4-10. Increases BDNF, NGF, and VEGF expression. Enhances dopaminergic and serotonergic neurotransmission. Neuroprotective and cognitive-enhancing.
What is the dosing protocol for Semax?+
Literature commonly references 300 mcg/day (low) to 600 mcg/day (maintenance) via Intranasal / SubQ, on a 4–8 weeks cycle. Educational reference only — a licensed Stackhaus Health provider sets any personalized protocol.
What is the regulatory status of Semax?+
Not on the 503A bulks list. Gray zone — approved as a nootropic in Russia.
Where can I access Semax?+
Research-grade Semax is available through Stackhaus Research. For a personalized, provider-reviewed protocol, consult a licensed clinician through Stackhaus Health.
More in Cognitive Enhancement
Used in these stacks
Semax appears in 1 research protocol in the Stackhaus Academy library.