KPV
Lys-Pro-Val (MSH fragment)
Mechanism of Action
C-terminal tripeptide of alpha-MSH. Binds melanocortin receptors (MC1R, MC3R) to exert potent anti-inflammatory effects without the hormonal effects of full alpha-MSH.
Key Benefits
- Potent gut anti-inflammatory (IBD, Crohn's, colitis)
- Systemic inflammation reduction
- Wound healing support
- Antimicrobial properties
Dosing Protocol
Strong anti-inflammatory for IBD, Crohn's, and colitis. Oral effective for gut-specific use.
Ideal Candidates
IBD, Crohn's disease, ulcerative colitis, systemic inflammation.
Side Effects & Safety
Generally very well-tolerated. Mild injection site reactions.
Regulatory Status
CompoundableOn the 503A bulks list. High value for GI inflammation protocols.
Frequently asked
What is KPV?+
KPV (Lys-Pro-Val (MSH fragment)) is a peptide studied for gut anti-inflammatory and ibd & crohn's support. C-terminal tripeptide of alpha-MSH. Binds melanocortin receptors (MC1R, MC3R) to exert potent anti-inflammatory effects without the hormonal effects of full alpha-MSH.
What is the dosing protocol for KPV?+
Literature commonly references 250 mcg/day (low) to 500 mcg/day (maintenance) via SubQ / Oral, on a 4–8 weeks cycle. Educational reference only — a licensed Stackhaus Health provider sets any personalized protocol.
What is the regulatory status of KPV?+
On the 503A bulks list. High value for GI inflammation protocols.
Where can I access KPV?+
Research-grade KPV is available through Stackhaus Research. For a personalized, provider-reviewed protocol, consult a licensed clinician through Stackhaus Health.
More in Immune & Gut Health
Used in these stacks
KPV appears in 1 research protocol in the Stackhaus Academy library.